Symbol
Name
ID

Rorc
RAR-related orphan receptor gamma
MGI:104856

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Splenomegaly
Disease(s) Associated with RORC	Splenomegaly
immunodeficiency 42

Mouse Phenotypes

increased thymocyte apoptosis

increased T cell apoptosis

decreased thymus weight

thymus hypoplasia

decreased thymocyte number

enlarged spleen

abnormal T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal T-helper 17 cell differentiation

decreased double-negative T cell number

increased double-negative T cell number

decreased double-positive T cell number

decreased B-2 B cell number

increased B-1a cell number

increased B-1b cell number

decreased NK cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased T cell number

abnormal T cell morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD4-positive, alpha-beta intraepithelial T cell morphology

abnormal CD8 positive, alpha-beta intraepithelial T cell morphology

abnormal splenic cell ratio

decreased IgG2c level

decreased IgG3 level

decreased IgG level

decreased IgM level

abnormal T cell physiology

abnormal T-helper 17 cell physiology

Availability

Mouse Genotype

Rorc^m1Btlr/Rorc^m1Btlr

Rorc^m2Btlr/Rorc^m2Btlr

Rorc^m3Btlr/Rorc^m3Btlr

Rorc^tm1.1Zsun/Rorc^tm1.1Zsun

Rorc^tm1Amj/Rorc^tm1Amj

Rorc^tm1Litt/Rorc^tm1Litt

Rorc^tm2Litt/Rorc^tm2Litt

Tg(CD2-Rorc)#Staka/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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